The Auditable Intelligence Layer for Clinical Trials

The brain for clinical trials —
governed, sourced, auditable.

AccuraTrials ingests your protocol and builds a governed model of the study — every eCRF, validation rule, and task carrying the exact clause it came from. Nothing is accepted until a human approves it, and every decision traces back to source evidence.AccuraTrials ingests your protocol and builds a governed study model — every eCRF, rule, and task cites the clause it came from, human-approved, fully auditable.

$50K revenue — already live in a real Phase I clinical trial.

No governed intelligence —
and every delay burns cash.

Every phase — setup, monitoring, amendments — runs on manual work with no shared intelligence layer. And every slip has a price.Every phase runs on manual work with no shared intelligence layer. Every slip has a price.

Setup
Finalised protocol → trial-ready: 3–4 weeks

eCRFs, specs, and validation rules hand-built per study, every time. No carry-forward. No intelligence.

Conduct
Deviations & tasks found late

No protocol-aware monitoring — deviations surface only when someone manually checks, and mandated follow-ups aren't auto-triggered.

Amend
Amendments ripple everywhere

One protocol change cascades through forms, rules, sites, training, and documentation — all reconfigured by hand, every time.

$23.7KPhase II direct cost, per day
$55.7KPhase III direct cost, per day
82%of Phase III trials get amended (avg 3.5×)
$535Kmedian Phase III amendment cost
"One trial can touch 20–50 systems. The greatest risk is not inside each system — it is in the handoffs between them."
Clinical Technology Leader · Japanese Contract Research Organization

The brain for clinical trials —
not another point solution.

An intelligence layer that ingests every source document and human decision, builds a governed model of the study, and monitors the trial across every clinical system.An intelligence layer that ingests source documents and decisions, builds a governed study model, and monitors the trial across every system.

Monitors data flowing between systems
Now
Protocol eCRFs, edit checks & specs
Site & subject data between EDC and CTMS
Trial data flowing into the TMF — auto-documented
Patient events ePRO & safety follow-ups triggered
All data flows one unified audit trail

Every output is source-linked,
human-approved, and audit-ready.

AccuraTrials ingests the protocol and generates a governed study model. Every eCRF, rule, and task carries its source clause — and requires human sign-off before it's accepted.The protocol goes in; a governed study model comes out. Every output carries its source clause and needs human sign-off before it's accepted.

01
Source
Where did it come from?

Every output maps to the exact protocol clause, section number, and page it was drawn from.

02
Reasoning
Why was this suggested?

The rule and logic that produced the output are captured and shown — never a black box.

03
Approval
Who accepted or changed it?

The reviewer, timestamp, and every edit are recorded before anything is accepted.

04
Audit
Is the full record intact?

Immutable, versioned, and reconstructable on demand for a monitor or an inspector.

Source traceability is an architecture problem — not a prompting problem.

0%Frontier LLMs, unprompted
15.3%Best model, even when explicitly prompted
100%Structured provenance architecture — AccuraTrials

Independent study: 5 frontier LLMs, 36 clinician-validated scenarios for source-evidence traceability.

First paid deployment
proves the wedge.

While building toward the full governance platform, we deployed the AccuraTrials EDC into a real Phase I trial and started charging. The intelligence layer is integrating on the same system — the architecture is proven in a regulated environment.We deployed the AccuraTrials EDC into a real Phase I trial and started charging. The intelligence layer runs on the same proven, regulated architecture.

1Phase I trial live on the AccuraTrials platform
$50Krevenue received to date, from a real deployment
100%of extraction-layer outputs mapped to a source document
WorkflowManual todayAccuraTrials
eCRF transcription~3 weeks48 hours
Amendment → downstream updatesWeeks, by hand1–2 days
Source-to-output traceabilityManual, partial100%, by design

Under the hood: a 200+ page protocol ingested, analyzed, and recalled through the extraction layer — every output mapped to its source document, then reviewed by a human before it goes anywhere near a patient record.

Protocol-driven data is the new standard.
Incumbents can't retrofit it.

Regulatory bodies are standardising on the protocol as the governing source of truth — not eCRFs or validation rules alone. Legacy tools were built the other way around. AccuraTrials was designed for what's coming.Regulators are standardising on the protocol as the source of truth. Legacy tools were built the other way around; AccuraTrials was designed for what's coming.

TransCelerate DDF

Protocol becomes the source of truth

Digital Data Flow makes the structured protocol the governing source for every clinical system — eCRFs, edit checks, and task flows generated from it, not hand-built and disconnected.

ICH E6(R3) GCP · 2023

Traceability & human oversight, mandated

Updated Good Clinical Practice explicitly requires structured, risk-based, auditable data management with full traceability to source and human-in-the-loop oversight.

FDA AI Framework · 2023

Every AI output must trace to evidence

AI in clinical development is acceptable only if every output traces to source evidence with documented human sign-off. AccuraTrials is built through that gate — not retrofitted to it.

CapabilityLegacy EDCAI toolAccuraTrials
Protocol-linked outputs
Human approval graphPartial
Full audit trailPartial
Source evidence on outputPartial
Conflict detection & review
"What stands out is not just the AI — it is the control around it. Every output remains visible, reviewable, and auditable."
Pratik Kulkarni · Senior Manager, Clinical Data Management · Amgen

A services business
waiting to become software.

Clinical trials spend $500K–$3M+ on manual data management per Phase II/III study. AccuraTrials replaces that spend with software — starting at study setup and expanding across the trial.Trials spend $500K–$3M+ on manual data management per study. AccuraTrials replaces that with software, starting at setup.

Entry · Phase I–IIILive today
$50–75K

Intelligence layer + EDC pilot. A 6-week engagement: protocol to sourced eCRFs, rules, and audit trail. Live today.

Platform · Year 1
$250K–$1M / yr

Deviation monitoring and source-linked AI actions across the study — priced against the manual work it replaces.

Clinical suite · Year 3+
$1M+ / yr

TMF, CTMS, ePRO, and safety integration. The same governed brain, a broader footprint across the full trial.

Turn one protocol into a governed, sourced, auditable study.

Protocol in, governed outputs out — every decision traceable to source evidence and signed off by a human. Live in a real trial today.

21 CFR Part 11ICH E6(R3) GCPHIPAAHuman-in-the-loop